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Programme

The symposium has now concluded, thank you for your interest in MSI events.

The program remains here for reference.

MSI 2016 Keynote Speaker

John Condeelis

Albert Einstein College of Medicine, New York

John Condeelis is The Judith and Burton P. Resnick Chair in Translational Research, Professor and Co-Chairman of the Department of Anatomy and Structural Biology at the Albert Einstein College of Medicine (AECOM). He is the director of the Cancer Center program "Tumor microenvironment and Metastasis" and co-Director of the Gruss Lipper Biophotonics Center of AECOM, a center dedicated to the development and application of optical imaging technologies. He is co-Director of the Integrated Imaging Program which is dedicated to the translation of methods using combined imaging modalities into clinically useful prognostics and treatment endpoints.

His research interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. He and his collaborators developed the multiphoton imaging technology and animal models used to identify invasion and intravasation microenvironments in mammary tumors. This led to the discovery of the paracrine interaction between tumor cells and macrophages in vivo, and the role of macrophages in the migration of tumor cells and their dissemination from primary tumors via blood vessels to distant metastatic sites. Based on these results, cell collection techniques were developed for the collection of migrating and disseminating macrophages and tumor cells. This led to the discovery of the mouse and human invasion signatures.

John Condeelis has devised uncaging, biosensor detection and multiphoton imaging technologies for these studies and has used novel caged-enzymes and biosensors to test, in vivo, the predictions of the invasion signatures regarding the mechanisms of tumor cell dissemination and metastasis. This work has supplied markers for the prediction of breast tumor metastasis in humans. Three of these markers, TMEM, MenaCalc and cofilin x p-cofilin, have been used in retrospective studies of cohorts of breast cancer patients to predict metastatic risk and are now in clinical validation trials. He has authored more than 280 scientific papers on various aspects of cell and cancer biology, biophysics and optical imaging. His current research remains on these topics.

MSI 2016 Invited Speakers

Paul Verkade

University of Bristol

Dr. Paul Verkade's research group is based at the University of Bristol where he also heads the EM unit of the Wolfson Bioimaging Facility, a fully integrated light and electron microscopy centre. His research group focuses on the development and application of microscopy techniques mainly for the study of sorting mechanisms in intracellular transport pathways. The main tools are electron microscopy (EM) and Correlative Light Electron Microscopy (CLEM) in which field he has published over 60 papers. Dr. Verkade is currently chair of the Electron Microscopy section of the Royal Microscopy Society. He has also organised and taught on several courses and workshops on subjects such as high-pressure freezing, Correlative Light Electron Microscopy (CLEM), and immuno EM. His lab is the current home of the EMBO practical course on CLEM (2012, 2014, 2016).

Valeria Nicolosi

Trinity College Dublin

Prof. Valeria Nicolosi is internationally regarded as a leading expert in the field of processing of low-dimensional nanostructures and high-end electron microscopy. She received a BSc with honours in Chemistry from the University of Catania (Italy) in 2001 and a Ph.D. in Physics in 2006 from the University of Dublin, Trinity College (TCD). In 2008 she moved to the University of Oxford with a UK Royal Academy of Engineering/EPSRC Fellowship. In 2011 she was awarded a European Research Council (ERC) Starting Grant to expand her work in nanomaterials and energy storage. In January 2012 she returned to Trinity College Dublin, becoming ERC Research Professor at the Schools of Chemistry, Physics and principal investigator in CRANN nanoscience centre. Today she is a PI in the newly founded SFI Advanced Materials and BioEngineering Research Centre (AMBER). Prof. Nicolosi has published more than 100 papers in high-profile international journals, such Nature, Science, Nature Nanotechnology, Nature Materials, and delivered more than 70 invited and plenary presentations at major conferences/institutions/public events. In 2012 she was awarded the RDS/Intel Prize for Nanoscience in recognition of her contribution to the field. In 2013 she was awarded the title of Young Scientist 2013 and invited to the World Economic Forum to present at the Annual Meeting of the New Champions in Dalian, China. She also won a WMB award as Woman in Technology 2013 in recognition of the impact of her work and her strong engagement with industry. In 2014 she was awarded a SFI President of Ireland Young Researcher Award (PIYRA), a highly prestigious one-million euro grant to sponsor her cutting-edge research in nanomaterials. In 2015 she was awarded a 2.5M euro worth ERC Consolidator Grant.

Chris Jones/Caroline Cartwright

Natural History Museum/British Museum London

Dr Caroline Cartwright is a Senior Scientist in the Department of Scientific Research at the British Museum. Her primary areas of scientific expertise cover the scanning electron microscope identification and interpretation of organics such as wood, charcoal, fibres, macro plant remains, shell, ivory and bone from all geographical areas and time periods in the British Museum's collections, including for CITES (Convention on International Trade in Endangered Species). Reconstructing past environments, charting vegetation and climate changes, evaluating sustainable resource use, and investigating bioarchaeological evidence from sites and data, all form important elements of her research and publications.

Chris Jones is Head of Core Research Laboratories at the Natural History Museum, London, incorporating the Imaging and Analysis Centre (IAC), Conservation Centre, Molecular Biology Labs and the recently formed Digitisation & Informatics Centre. Chris trained as an earth scientist and has specialised in the application of electron microscopy (standard high vacuum, variable pressure and field emission SEM) for the imaging and analysis of specimens ranging from naturally occurring samples from the Museum's extensive collections through to materials and synthetics. Prior to working at the Museum Chris worked in the Geology department at Oxford Brookes University and also spent eight years as an applications scientist in industry, working for Hitachi High Technologies, centred on the development of electron microscopy instruments and methods, and their application is industry and academia. Chris has published a number of peer reviewed papers ranging from ultrastructure in bryozoans through to the natural mineral pigments in works of art, and contributed book chapters on the application of electron microscopy.

Alex Dazzi

Universite Paris Sud

Prof. Dazzi has a research program focused on nanoscale IR Spectroscopy, a technique that he invented. Specific research objectives including applying the technique to solve interesting problems in microbiological and cellular imaging, while simultaneously pushing the limits of the technique itself. He obtained his PhD in Physics in 1998 at the Université de Dijon, and did post-doctoral work at the Centre de Recherche Paul Pascal at Bordeaux. This training gave him a solid background in near field optics techniques. In 2000 Dr. Dazzi took an associate professor position at the CLIO FEL facility, where he worked on near-field techniques in the infrared region. After initially focusing on infrared SNOM, Pr. Dazzi invented a technique called Photothermal Induced Resonance (PTIR) that enables an AFM probe to act as a detector that can provide information on infrared spectroscopy at the nanoscale. This patented technique has been commercialized by Anasys Instruments in its nanoIR product. He was the 2009 laureate for France's national instrumentation prize from the Societeacute; Francaise Division de Chimie Physique. He was also associated to the R&D 100 awards in 2010 and the microscopy today's 2011 innovation award for the nanoIRTM. In 2014, he received the Ernst Abbe award from the New York Microscopical Society. In 2015, Dr. Dazzi obtained a tenure Professor position at the Universiteacute; Paris-Sud.

Julian Moger

Exeter University

My research is in the field of Biophotonics - the interface between Biology and Photonics that deals with the interaction between light and biological systems. My enthusiasm for Biophotonics began with my PhD in 1999 where I developed Doppler Optical Coherence Tomography for imaging capillary blood flow. As a Postdoctoral researcher I worked closely with the pharmaceutical industry to develop spectroscopic techniques for high-throughput screening of drug compounds. My research now focuses on the development and application of nonlinear optical microscopy to tackle compelling problems related to human health. I currently lead the Nonlinear Biophotonics Research within the Biomedical Physics Group at Exeter where I have established a state-of-the-art facility that is strongly supported by staff with expertise in the development and biological application of nonlinear optics. By working in close partnership with industry the fundamental research in my laboratory supported by the EPSRC and BBSRC is successfully being translated into commercial R&D applications.

Jeremy Simpson

University College Dublin

Jeremy Simpson carried out his PhD work at the University of Warwick (UK). After post-doctoral work at the Scripps Research Institute in San Diego (USA) and the ICRF in London (UK), he was awarded a long term EMBO fellowship and spent nine years at the European Molecular Biology Laboratory (EMBL) in Heidelberg (Germany). In 2008 he was appointed as Professor of Cell Biology at University College Dublin, Ireland. His lab currently applies high-throughput imaging and RNA interference technologies to study intracellular trafficking events, organelle structure and organisation, the internalisation pathways taken by synthetic nanoparticles on exposure to cells, and how the cytoskeleton responds to cellular exposure to nanomaterials and nanosurfaces. His lab also develops novel software tools for image analysis. He has authored over 80 peer-reviewed articles, including articles in Nature Cell Biology, Nature Methods and Nature Communications, and a number of book chapters. He runs the UCD Cell Screening Laboratory (www.ucd.ie/hcs), he is currently is the Head of School of Biology & Environmental Science and the Vice Principal (International) in the UCD College of Science.

Martin Leahy

National University of Ireland, Galway

Martin Leahy completed a DPhil at the University of Oxford and he and a colleague established Oxford Optronix Ltd., where he was Director of R&D. From 1995 he had various research and teaching posts at the University of Oxford. He then joined the Stokes Research Institute where he conducted industry led R&D and later the Physics Department at the University of Limerick where led research groups in energy and biophotonics and lectured in physics. He has secured more than €7M in external R&D funding since 2003. He is an adjunct professor at the Royal College of Surgeons, Fellow of the Institute of Physics, Fellow of the Royal Academy of Medicine in Ireland and Fellow of SPIE. He is a co-chair, executive organizing committee member, panel moderator for SPIE Photonics West BiOS in San Francisco and Editorial Board member of the Journal of Biomedical Optics. and host of the BioPIC European Bioimaging conference. Prof Leahy was founding MD of Limerick West Windfarms Ltd. and Millstream Energy and PI on the research projects that spun out Biomass Heating Solutions Ltd. and Wheelsbridge AB. Since his return to full-time academia, he has played a leading role in graduate biophotonics education through NBIP, UL and the Biophotonics and Imaging Graduate Summer School. Since 2010 he has delivered more than 20 international invited lectures and published more than 40 ISI journal articles. He is currently Chair of Applied Physics at NUI Galway and was elected to Council of the Royal Microscopical Society in 2015.